November 11

What causes infertility in woman ? 5 causes of infertility in a woman

What causes infertility in woman ? 5 causes of infertility in a woman

Over the past 60 years, the fertility rate - measured in births per woman - has steadily declined worldwide by a total of 113%. What causes infertility in a woman ?1 One of the reasons, besides the decline in male fertility, is the increasing infertility in women. This article provides an overview of the most important impacts on or causes of infertility in a woman .

Worldwide decline in fertility rate

Whereas 5.1 children were born per woman in 1964, the figure was only 2.1 in 2020 (1.5 in the European Union). This decline is due not only to biological but also to societal causes. This article examines what causes infertility in a woman predominantly in the context of biological and environmental impairments. In essence, five areas are to be pointed out which have a notable influence on female fertility and which, of course, are not to be considered complete and are only intended to provide an overview. Multiple causes of infertility in a woman have to be discussed, to get an idea on the complexity of the situation.

Diagnosis infertility

A diagnosis of 'infertility' is made, if after 12 months of regular and unprotected sexual intercourse, no  clinical pregnancy has occurred.2 Since the introduction of the assisted reproduction technology (ART), the diagnosis of `infertility` has been weakened and replaced by `subfertility`, since reduced natural fertility may be `treated` with medical assistance.

"Female infertility affects one in seven couples in the Western world and one in four, or 186 million women, in the so-called developing world."

Literature data on the incidence of infertility vary widely because, on the one hand, absolute numerical values increase with population growth and, on the other hand, different studies incorporate different definitions in terms of the length of time a couple tries to become pregnant.

How common is infertility among women?

On average, depending on the study, 48.5 mio.3 or 72.4 million women4 of reproductive age are affected by female infertility, regardless of a country's level of development. Female infertility affects one in seven couples in the Western world and one in four couples in the so-called developing countries, or 186 million women.5 or 186 million women.6 In some regions of the world, including South Asia, some countries in sub-Saharan Africa, the Middle East and North Africa, Central and Eastern Europe, and Central Asia, infertility rates reach as high as 30%.3 However, fertility rates measured by the average number of live births per woman are significantly higher in developing countries, led by Africa, than in Western countries, particularly Europe and North America.2

The main factors on what causes infertility in a woman

The most important factor influencing the spontaneous conception probability of couples is the age of the woman.7,8 Other factors include the period over which involuntary childlessness extends, infertility due to disease, lifestyle and environmental factors, and of course other factors affecting male fertility, such as the decline in semen quality, which will be discussed in detail in a separate article.9 In addition, it is also important to take into account the population reduction efforts that have been ongoing for decades using contraceptive vaccines,10, 11, 12 which are discussed in detail in our article "Population Reduction by Immune Contraception?" and our articles on the impact of currently administered mRNA injections on male fertility, as well as reproductive toxic effects and the increase in pregnancy complications in women.

"The most important factor affecting the spontaneous conception probability of couples is the age of the woman."

1. What causes infertility in a woman ?  Age of the woman

Even in populations with natural fertility, a marked decline in fertility can be observed in young women from the age of 25. By age 41, fertility is already reduced by 50% and comes to a complete halt by age 50. The table below provides an overview of an observational study published in 2014 that evaluated historical data on 58,051 women.13

What causes infertility in a woman natural fertility population natural decrease in female fertility increase in female infertility Pure Fertility
Figure 1: Increase in female infertility in populations with natural fertility according to Eijkemans et al. (2014).13

Although these are older data, the proportions of the age-related reduction in fertility can also be applied to the current social situation. It is believed that this natural part of what causes infertility in a woman is predominantly due to the depletion of oocytes already formed in the womb during the early fetal phase of development. It is also known that the quality as well as other factors significant for fertilization decrease with age.2 Based on the increase in the age to first birth over the past decades, it can be assumed that age is the main cause of infertility in a woman.7, 8

2. What causes infertility in a woman ?  Period of involuntary childlessness

The majority of pregnancies occur in the first six months of regular, unprotected sexual intercourse. The approximately 10% of couples who still do not conceive after 12 months are considered subfertile. However, even in this group, 55% of couples are still able to have a live birth in the subsequent 36 months. Only about 5% of couples remain childless after 48 months. In these couples, the chance of spontaneous pregnancy drops to almost zero, and they are considered infertile.9

3. What causes infertility in a woman ?  Pre-existing conditions

Disease-related causes of infertility in a woman may be associated with, for example, premature ovarian failure, endometriosis, or tumor disease.2 Moreover, the fertility of both sexes (compare our article on what causes infertility in men) affected by both reduced and excessive activity of sex hormones, infections or systemic diseases.2

4. What causes infertility in a woman ?  Lifestyle

Lifestyle-related factors may act indirectly beyond direct effects on fertility by promoting or triggering disease.2, 14 These include an unbalanced diet, lack of exercise, smoking, and increased consumption of alcohol and medications as possible causes of infertility in a woman . It is also known that calorie-restrictive diets and excessive exercise influence the frequency of ovulation.2

"For every 100mg increase in daily caffeine intake, a threefold increase in the miscarriage rate of pregnant women was observed."

Caffeine appears to have a particular effect on pregnancy and is associated with miscarriages and spontaneous abortions.14

4.1 Caffeine, the involuntary "morning-after pill"?

An increased incidence of unexplained miscarriage was observed above 150mg of caffeine (approximately 2 cups of espresso), with 150-300mg (2-5 cups of espresso) leading to a threefold increase and >300mg (one cup of `Starbucks Grande`) leading to a 16-fold increase in the incidence of unexplained miscarriage.15 For every 100mg increase in daily caffeine intake, a threefold increase in the miscarriage rate of pregnant women was observed.

What causes infertility in a woman Infertility study shows repeated miscarriages due to caffeine intake Pure Fertility
Figure 2: Effect of caffeine intake (amount in mg per day) on the increase (in %) of unexplained repeated miscarriages during periconception and at the beginning of pregnancy (after controlling for pregnancy-related symptoms). Graph from own compilation, after Stefanidou et al. (2011).15

4.2 Phytoestrogens - are all "healthy" food plants really our friends?

A whole range of plant foods contain naturally occurring secondary plant compounds with estrogenic and/or antiestrogenic effects - which act as phytoestrogens, among other things. They are found in many foods, including beans, sprouts, cabbage, spinach, soybeans, grains and hops. Consumption of high levels of phytoestrogens can have adverse effects on reproductive functionality, including affecting sex hormones and even infertility. In particular, soy, which is popular among vegetarians and vegans, has extremely high levels of phytoestrogens.16, 17 Plant compounds may be an underestimated factor on what causes infertility in a woman . More details on this can also be found in our article on the decrease in male fertility.

5. What causes infertility in a woman ?  Environmental stress

While men constantly renew their sperm from puberty to old age, in women the number of eggs available for their lives is already fixed at birth. As a result, women's fertility is more severely and sustainably threatened by harmful environmental stresses than that of men. Among the most widespread, female infertility-promoting and greatly increasing18 environmental pollutants, include heavy metals, air pollution, and more than 1,000 synthetic chemical disruptors affecting the endocrine system,7 such as plastics (bisphenol A), plasticizers (phthalates), industrial solvents/lubricants and their by-products, agricultural toxins (pesticides, fungicides, herbicides, insecticides), and pharmaceutical ingredients.14, 19, 20

What causes infertility in a woman Increasing infertility Decreasing fertility due to exposure of pregnant women to chemicals in the United States Pure Fertility
Figure 3: Increase in exposure of pregnant women to over-the-counter current and emerging chemicals in the United States. Taken from Buckley et al. (2021)18

5.1 Hormone-like disruptors affect fertility: how are we exposed to phthalates?

A large proportion of these chemicals, particularly phthalates, are found in many consumer products, including building materials, household goods, cleaning products, clothing, cosmetics, personal care products, pharmaceuticals, dentures, medical devices, dietary supplements, herbal remedies, medical devices, children's toys, plasticine, food packaging, and motor vehicles.21 These chemicals can be found in various biological fluids as a result of exposure, including sera, urine, amniotic fluid, and breast milk.19

"Among the most widespread environmental stresses negatively affecting female fertility are heavy metals, air pollution, and more than 1,000 synthetic chemical disruptors affecting the endocrine system..."

What causes infertility in a woman Infertility due to environmental exposure pregnant mother Endocrine Disrupting Chemicals (EDCs) epigenetics transgenerational effect Pure Fertility
Figure 4: A pregnant mother's environmental exposure can inadvertently introduce endocrine disrupting chemicals (EDCs) into the embryo's finely tuned hormonal milieu, from Papalou et al. (2019)19

5.2 Reduced fertility due to electromagnetic waves

One of the most important, perhaps the most important strongly increasing risk factor on what causes infertility in a woman , is the increase of weak electromagnetic waves in the high frequency range (microwaves) due to the expansion of wireless communication in the context of digitalization. In pregnant mice, the impairment of the placenta by increased oxidative stress, DNA damage as well as apoptosis be observed through 2-4 hours of irradiation at a distance of 30-60cm.22  We suspect that EMF might be the most underestimated and highly dangerous, environmental stressor in the context of what causes infertility in a woman . For more on the dangers of weak electromagnetic waves, see our article "Reduced sperm quality, these are the causes". The possible importance of consistent shielding of the upper body of pregnant women by shielding fabrics, is mentioned here only in passing.

"One of the most important, perhaps the most important rapidly increasing risk factor on what causes infertility in a woman , is the increase in weak electromagnetic waves in the radio frequency range (microwaves)..."

Finally, a large number of published field reports and scientific studies are now available reporting alarming effects of Covid-19 injections on female reproductive health. For more detailed information on the adverse effects of Covid-19 gene-technology based injections on female fertility (reproductive toxicity and increase in pregnancy complications) as well as male fertility, please refer to the articles listed.

IMPORTANT THINGS AT A GLANCE!

  • -113% fertility rate worldwide since 1960.
  • Fertility rate in 1964 still 5.1 children per woman; in 2020 only 2.1 and in the EU 1.5 children.
  • 48 - 72 million women worldwide are unwanted childless.
  • 1/7 couples in the Western world are affected by female infertility.
  • Natural decline in fertility at age 25 by 4.5% and age 45 by 90%.
  • Woman's age as the most important factor in the probability of conception....
  • ... followed by the period of involuntary childlessness as well as disease-, lifestyle- and environment-related influences.
  • Environmental toxins and wireless data transmission (WLAN, UMTS, etc.) play an increasing - perhaps the decisive - role.
  • Up to 1,700% increased risk of miscarriage from coffee.
  •  Contraceptive vaccines as an underappreciated and understudied influence.
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