Male infertility: are mRNA vaccines toxic to reproduction? 7 dangers for male sperm quality
1. No exclusion of male sterility for all manufacturers.
So far, all manufacturers have definitely neglected to include any and sperm quality as a result of Covid-19 mRNA injections, including possible effects on offspring, which was also noted and confirmed by the UK health authority.1 But even if this were the case, the time for reliable statements regarding long-term effects on reproductive toxicity including the risk of sterility and reduced sperm quality is still far too short. The package insert (as of 12/2021) of the Pfizer-BioNTech active ingredient states the following: "COMIRNATY has not been evaluated for its potential for carcinogenicity, genotoxicity, or impairment of male fertility."2 In the only animal study to exclude female reproductive toxicity,3 the males used for mating were completely untreated according to Pfizer (p. 29).4
2. Covid-19 mRNA injection and sperm-quality.
From the listing of 'side effects of special interest' of Pfizer's post-marketing study (p. 30)5 it can be inferred that anti-sperm antibodies - i.e. an autoimmune reaction - were observed as a result of the injections. According to inviTRA, a certified medical journal founded by physicians and fertility experts, "The presence of antisperm antibodies (ASA) in the ejaculate is an immunological cause of male infertility. The attachment of antibodies to sperm impairs their motility and makes the sperm's journey to the egg very difficult or even impossible." 6 For the development of `vaccines` for immune contraception and other anti-fertility vaccines, please refer to our article "Population reduction through immune contraception?" .
"...75-120 days after the second injection, a significant decrease in both sperm concentration by -15.4% and total motile sperm count in the ejaculate by -22.1% was observed."
Already available cautionary studies7, 8, 9, 10, 11 which investigated the effects of mRNA injections on sperm-quality without detecting any effects, were mostly too short, included too few study participants and measurement time points, and in all cases were set up without a control group in order to obtain publishable results as quickly as possible. However, a recently published Israeli study, which included a longer observation period, observed a significant reduction in sperm-quality as a result of COMIRNATY injections.12
2.1 First study provides evidence for reduced sperm-quality and potential sterility in sperm donors after mRNA injection
Including 37 sperm donors (220 semen samples), sperm-quality was recorded both before the first, and 15-45, 75-120, and >150 days after the second mRNA injection.12 In the period 75-120 days after the second injection, a significant decrease in both sperm concentration by -15.4% (9.5-12 million / ml), and total motile sperm count in the ejaculate by -22.1% (27.3 - 31.2 million / ml) was observed. The total volume of the ejaculate as well as the were not significantly affected.
For this study, too, it must be mentioned that it is a very small sample and no control group - but several measurement time points and a significantly longer measurement period - were included. It is interesting to note that samples after the third injection (booster) were not included in the study. A reason for this procedure was not given by the authors and leaves room for speculation. The authors' interpretation and classification of the results is also astonishing. The normalization of the parameters (which were also not consistent for all analyses) in the last measurement (>150days) was considered a supporting argument for the tolerability of the mRNA injections.
"It is interesting to note the reference that samples after the third injection (booster) were not included in the study. No rationale for this was provided by the authors, leaving room for speculation."
2.2 All-clear and trivialization of potential sterility due to flawed and inadequate studies
Various other studies conducted since then have not found an increased incidence of male sterility or significant negative effects on reproductive toxicity or sperm-quality as a result of the mRNA agents.7-11 In fact, in a previous Israeli study, a significant improvement in sperm-quality (Increased sperm count and motile sperm count) was observed as a result of the second injection.9 However, a conclusive explanation for these observations was not provided by the authors and this study also did not consider measurements as a consequence of the `booster injections`. Another study already conducted in Miami in December 2020 also observed a significantly increased sperm count after the second injection.2 However, according to the authors, this is within the normal range of variation - which may be due to prolonged abstinence prior to the second sampling.
2.2.1 No control group
It should also be noted that all the studies conducted involved small sample size of 33-75 men, and no control group was examined - an important criterion for a scientifically accurate study. In another Israeli study, WHO reference-data were used as baseline.11 In an Italian study, supplemental inflammatory markers (IL-6) were collected,8 although again no differences were observed and thus neither reproductive toxicity nor male sterility could be detected.
"These facts provide clear evidence that a few batches are significantly more toxic than the majority of batches!"
2.2.2 Too few study participants
The disadvantage of using a small sample size is of particular importance in that well over 90% adverse reactions have been reported in association with a very small number of batch numbers. This can be inferred from data compilations of official databases, with the frequency of reported adverse reactions for a few batches including as many as 4,900 reported adverse reactions and as many as 90 deaths.13 These facts provide a clear indication that a few batches are significantly more toxic than the majority of batches! In order to be able to meaningfully interpret study results, in the future (1) significantly larger data sets (samples) must be analyzed and (2) the respective batch number must be specified for all included injections and integrated into the analyses. A possible cause for the occurrence of negative effects in only one12 out of a total of six studies could therefore be the presence of toxic batches among the seed samples investigated.
2.2.3 Investigated period too short to detect deprived sperm-quality
Also, the very short study period does not allow any assessment with regard to possible long-term consequences. However, it is worth noting the recommendation of the study leader, Dr. Ranjith Ramasamy, during the conduct of the study in Miami, that men who would like to father children in the future should consider having a sperm sample frozen (cryopreservation) prior to vaccination in order to rsik a later desire to have children due to possible reproductive toxicity and the associated reduced sperm-quality and even infertility.14
However, complementary to the few studies on semen quality of insufficient quality after Covid-19 injections, there is already concrete evidence15, 16, 17 for risks that can be derived from the ingredients of the Covid-19 injections. In addition, the currently known toxic effects of the spike protein, which is synthesized by our cells due to the administered mRNA, must be considered, as will be described below.
3. Male infertility and reduced sperm-quality due to spike protein & mRNA??
It must be assumed that cells of all affected tissues (incl. testis and prostate) will be destroyed according to the intended mode of action of the mRNA injections by a process known as process itself produce spike proteins18 - with all the associated dangers of reproductive toxicity. The Sars-CoV-2 spike protein (in general) can damage the body by several pathways, affecting women equally and resulting in a corresponding other articles is explained together with the reproductive toxic hazards.
3.1 Suppression of DNA repair and other known mechanisms of damage
According to a recent study, the Sars-CoV-2 spike protein causes suppression of adaptive immunity by inhibiting DNA damage repair.19 This represents a possible mechanism triggered by spike proteins as well as injections based on them. The potential risk is due to the desired mode of action of mRNA injections, which causes the production of spike proteins in the body. The authors hypothesize19 that the involvement of viral spike protein subunits in suppressing DNA damage repair suggests that spike-based 'vaccines' may thus also result in suppression of DNA repair.
"For unexplained reasons, the percentage of intact mRNA in commercial batches is worryingly low at 55%-78%."
More advanced mechanisms include cardiovascular complications due to damage to endothelial cells (cells in blood vessel walls),20 autoimmune reactions due to binding of spike proteins to organ surfaces,21 the release of destructive anti-spike antibodies22 as well as gene integration of the mRNA coding for the viral spike protein.19, 21, 23, 24 Whether genome modification can also occur through the mRNA injections is discussed in the following chapter.
3.2 No protection of the testes by selective barrier
The germ cells in the germinal epithelium of the testis are normally separated from the blood circulation by a selective barrier (Sertoli-Sertoli Junctional Complex), which protects the developing spermatozoa, which are highly susceptible to environmental toxins due to their high division rate, from contaminants circulating in the blood. Obviously, lipid nanoparticles containing mRNA are not stopped by this barrier,17 which is explained in more detail in the last chapter. Thus, it can be assumed that spike proteins produced elsewhere in the body and circulating in the bloodstream can also reach the testes and prostate, where they may have adverse effects including male sterility. This assumption can be inferred from evidence of Sars-CoV-2 viral RNA detected in sperm of infected Covid-19 patients19, 20 and could possibly lead to impaired fertility (reproductive toxicity and impaired sperm-quality) in the long term.25
3.3 Lack of clarity about differences between batches, composition and quantity of ingredients contained.
Worrying are statements of an anonymous whistleblower, who according to his own information is a development engineer at the "vaccine" manufacturer Moderna and already informed in December 2020 in an anonymous forum that only a part of the contained mRNA codes for the spike-S protein.26 According to his information, the unknown mRNA material encodes mutated versions of a protein called `CYP19A1`. At this point, it must be made clear that neither the identity nor the information on the professional background of the whistleblower can be verified for accuracy in any way. However, the following substantive points can be verified and substantiated, and further effects related to the female reproductive tract will be explained in a supplementary article...:
- Expression of the enzyme CYP19A1, triggered by Sars-CoV-2 in the lungs of men, is associated with both worse Covid-19 disease progression and reduced testosterone levels.27
- The British Medical Journal (BMJ) published information in March 2021 regarding inconsistencies in mRNA content between BioNTech-Pfizer's clinical and commercial batches. For unexplained reasons, the percentage of intact mRNA in the commercial batches is worryingly low at 55%-78%28 According to the BMJ, the information comes from a cyberattack at the European Medicines Agency (EMA) and involves documents from the approval process and email histories of EMA regulators.
Whether there is corresponding mRNA material in the Moderna batches cannot be determined at the present time, but it seems to be within the realm of possibility. Should this prove to be the case, concerns regarding male reproductive health, including possible sterility, are more than justified against this background.
"It was further demonstrated that viral Sars-CoV-2 RNA could also be reverse transcribed and integrated into the genome of cultured human cells and expressed in patient-derived tissue via the pathway described above."
4. Sterility and reduced sperm-quality due to genome alterations (genetic manipulation) - is it possible?
Although not yet explicitly demonstrated, it is likely that the mRNA encoding the spike protein can also be integrated into the human genome, as detailed below. It has been known for some time that RNA can be reverse transcribed into DNA by an enzyme called `reverse transcriptase'.23 This enzyme occurs in all before. In the course of human evolution, gene sequences of viral origin were repeatedly incorporated into human DNA and thus integrated into the genome. Today, these account for up to ∼8% of the human genome.29 The in contribution to effects on women's fertility Syncytin-l is an example of retroviral gene information integrated into the human genome. Spermatozoa can directly transform exogenous RNA into complementary DNA (cDNA) and - in which this cDNA is packaged - to the fertilized egg cell. These plasmids are able to replicate in the developing embryo and colonize the tissues of the fetus.24
4.1 Genome alterations by endogenous reverse transcriptase possible?
Furthermore, it was shown that via the pathway described above, viral Sars-CoV-2 RNA could also be reverse transcribed and integrated into the genome of cultured human cells and expressed in patient-derived tissue.23 One of the counter-arguments put forward by "vaccination proponents" regarding the possible risk of genome alteration through the injections was that, in contrast to natural retroviruses, the enzyme reverse transcriptase is not contained in the mRNA active substances. The special feature of the previously mentioned study, however, is that the reverse transcription here is based exclusively on elements took place, which account for ∼17% of the human genome.15 Thus, the rewriting and also integration into the human genome of mRNA fragments is also possible by endogenous reverse transcriptase (LINE-1 elements) without the presence of exogenous retroviral reverse transcriptase, the latter thus not being able to constitute an exculpatory argument for the common mRNA active ingredient.
"BNT16b2 mRNA was shown to be "rewritten" into DNA in human liver cells in less than six hours..."
A study published in January 2022,30 investigated the effect of BNT16b2 mRNA (injection from BioNTech/Pfizer) on human liver cells. BNT16b2 mRNA was shown to be "rewritten" into DNA in human liver cells in less than six hours, assuming as a possible mechanism the endogenous LINE1 elements described above. The authors expressed concern that the mRNA introduced by BNT162b2, as a result of reverse transcription into DNA, could compromise the integrity of genomic DNA, possibly adding genotoxic side effects to the dangers of reproductive toxicity and the possible associated risk of sterility.
5. Nanoparticles - a known hazard to male reproductive health and sperm-quality.
Several review articles15, 16 document the reproductive toxic effects including the risk of deprived sperm-quality or sterility by nanoparticles on the male reproductive tract in both cell and animal studies. Well known are the so-called lipid nanoparticles (LNP) - a special form of nanoparticles - which serve for the transport of the contained mRNA into the cells and are a declared ingredient of the mRNA injections.
"Accumulation of LNPs in the male reproductive organs ... has been demonstrated in both the prostate and testes."
In addition, several independent published laboratory analyses confirm that a variety of other nanoparticles are present in the injections beyond the known LNPs, including various toxic and precious metals31, 32 as well as the extremely toxic carbon compound 'graphene oxide'.32 These are undeclared ingredients, disputed both publicly and scientifically, which cannot be warranted by the mode of action justified by the manufacturer.
5.1 Sterility by crossing all biological barriers?
Nanoparticles cross all biological barriers, which is also the reason for their toxic potential on male fertility and even sterility.16 Harmful effects can generally be identified at the cellular and organ level as well as in the hormonal system, in particular reduced fertility (sperm-quality) due to reduced motility and sperm count as well as morphological changes. The following figure provides an overview.
5.2 Lipid nanoparticles - a declared reproductive toxicant ingredient potentially leading to sterilityhe Ingredient potentially leading to sterility
A declassified Pfizer document published in spring 2022, shows the results of studies on the bio-distribution (distribution in the body) of BNT162b2 in rats.33 The data show a distribution of the known toxic34, 35, 36 and highly pro-inflammatory37 LNPs, which include the mRNA, and accumulate in blood plasma and all organs.
5.2.1 Accumulation of LNP in testes and prostate gland was known to the manufacturers
Accumulation of LNPs in the male reproductive organs-albeit to a much lesser extent than in the female reproductive organs-was detected in both the prostate and testes, clearly emphasizing the potential reproductive toxicity and associated risk of male sterility.33 The highest concentration in the testes was observed after 48 hours (0.320 μg/g) and in the prostate after 24 hours (0.183 μg/g)-underlining the potential dangers of rewriting mRNA to DNA23, 30 in sperm. The manufacturer, Pfizer, has been aware of these results since at least September 2020.33 The results were also confirmed, with only slight variations, by a confidential Japanese government investigation, the results of which have been available to the (informed) public since as early as May 2021.17
"This product is intended for research purposes - not for diagnostic or therapeutic purposes in human or veterinary medicine."
5.2.2 Potential sterility due to unapproved ingredient! What is the truth about "SM-102"?
According to the official data of the US Centers of Disease Control and Prevention (CDC), the active ingredient mRNA-1273 (Moderna) contains a substance called "SM-102" as one of the listed LNPs.35 The manufacturer, Cayman Chemical, provides the following application information in its Safety Data Sheet:36 "This product is intended for research purposes - not for diagnostic or therapeutic purposes in human or veterinary medicine." Furthermore, SM-102 has "reproductive effects" and is described by the manufacturer as "highly flammable in liquid and gaseous form". as well as "highly hazardous to health." and "carcinogenic to humans",36 according to the highest class 1A for carcinogenic substances of the International Agency for Research on Cancer (IARC)38 classified. Any doubters and 'fact checkers' who are of the opinion that the dangers relate only to the alcohol contained, are referred here to the Substack article by Dr. Jessica Rose.38
6. Reproductive toxicity and sperm quality impairment by graphene oxide- fact or fiction?
Different forms of graphene oxide were found in the serum of both Pfizer-BioNTech and Moderna (reduced graphene oxide or graphene hydroxide) and Janssen (reduced graphene oxide).32 Dark-field microscopy studies of the blood of 1006 symptomatic `vaccinated` patients confirmed the presence of graphene-like structures in the blood.39 Whether graphene oxide is present at all or possibly only in certain batches is hotly debated and cannot be conclusively answered at this time. Other published studies could not find graphene oxide, but various dark-field microscopic studies without peer review confirm the results of Young (2022).32 Whether this method is sufficient in its conclusiveness is, however, debatable.
According to the already mentioned review article16 graphene oxide exposure has been associated with structural damage to the testes, with high concentrations being toxic to the spermatogonial stem cells thus clearly indicating reproductive toxicity and thus danger to sperm-quality. In cell studies, high concentrations of 400μg/ml (but not 100 μg/ml) resulted in increased DNA damage within 24 hours, and morphological changes as well as reduced viability, membrane integrity and oxidative stress of SSCs.40 The formation of complex molecules and nanotechnological structures 32, 40 and their potential use, as well as the 'blood clots' removed from the bodies of deceased persons,41 are only mentioned here in passing.
6.1 Altered composition of blood clots
However, it seems important to note that the `blood clots` of `inoculated` individuals had a greatly altered composition, with nutritive elements (iron, zinc, magnesium, etc.) being markedly reduced and elements with particularly good electrical conductivities (tin, aluminum, sodium) - which were also found in the injections 31, 32 being markedly increased and appearing to accumulate in the `clots`.
7. Additional reproductive toxicity information from US military database.
Observations by whistleblower publications of data from the U.S. Department of Defense Medical Epidemiology Database (DMED), support concerns about male reproductive toxicity.42, 43 The data show a 350% increased incidence of male infertility and a 369% increased incidence of testicular cancer in 2021 compared with the previous years 2016-2020. However, the data must be interpreted with caution. According to a comprehensive analysis44 they cannot be correct.
"The data show a 350% increased incidence of male infertility and a 369% increased incidence of testicular cancer in 2021 compared with the previous years 2016-2020."
For more detailed information on contraceptive vaccines, sterility and pregnancy-complications as a result of Covid-19 injections, as well as reproductive toxic effects in women, please refer to the articles "Population reduction through immunocontraception?", "Pregnancy-complications after Covid vaccination?" and "Vaccine side effect infertility: 5 dangers."
[...] circumstances described in our supplementary articles on Covid-19 injection and the associated dangers to male and female fertility, raise the question of whether the administered [...]
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[...] supplementary articles on Covid-19 injection and the associated dangers to male and female fertility described circumstances raise the question of whether the [...]
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[...] have already been explained in detail on our blog. Also on the toxicological risks from vaccination side effects on male fertility and the literature published on this so far, has been discussed in detail [...]